Interfase Plus

Interfase Plus

Klaire Labs
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Antibiofilm enzyme combination with EDTA

InterFase® Plus combines the same unique enzyme formulation found in InterFase® with ethylenediaminetetraacetic acid (EDTA). The presence of calcium, iron, and magnesium is essential for biofilm creation and serves to cross-link the anionic regions of polymers. InterFase® Plus includes EDTA which binds the metals needed for biofilm formation. InterFase® Plus can be used for maximum antibiofilm activity.

Breaking through the biofilm matrix

InterFase® is a highly specialized enzyme formula that supports normal gastrointestinal function and microbiota by assisting enzymatic degradation of biofilm communities of bacteria and yeast allowing for repopulation with salutary species. While digestive enzymes are taken with meals to help digest food, the enzymes in InterFase® are taken between meals to help degrade bacterial and yeastbiofilm communities, a complex aggregation of microorganisms embedded in a protective extracellular, polymeric matrix. Biofilms make it enormously difficult to shift the balance of microbiota. InterFase® has documented ability to lyse polysaccharides making up biofilm matrices as well as degrade bacterial and yeast cell wall structures. This innovative enzyme formulation provides a synergistic combination of glucoamylase, cellulase, hemicellulase/pectinase, beta-glucanase, protease/peptidase complex with dipepticlyl peptidase-IV (DPP-IV) activity, lysozyme, chitosanase, and Serratia peptidase that targets and disrupts GI bacteria and yeast biofilms.For enhanced antibiofilm activity, InterFase®Plus combines the enzymes in InterFase® with disodium ethylenediaminetetraacetic acid (EDTA), a compound that binds the metals needed for biofilm formation.

InterFase® is a unique enzyme formulation especially designed to disrupt gastrointestinal bacterial and yeast biofilm communities. Enzymes in InterFase® are selected for their ability to lyse the extracellular polymers commonly found in biofilm as well as degrade bacterial and yeast cell wall structures. The lytic effect of InterFase® on biofilm has been documented using the well-established MBEC™ P&G assay for antibiofilm activity. InterFase® Plus includes ethylenediaminetetraacetic acid (EDTA) which binds the metals needed for biofilm formation

Suggested use

Depending on age and size, 2 capsules, 1 to 4 times daily between meals or as directed by a healthcare professional. The capsules should be taken away from meals to maximize the enzyme effects.

Drug interactions

Some forms of proteolytic enzymes have been shown to reduce platelet aggregation and thus may theoretically potentiate the effects of anticoagulant medications such as Coumadin. Proteolytic enzymes with DPP-IV activity may in theory interfere with DPP-IV inhibiting drugs. Carbohydrase enzymes may increase the intestinal availability and absorption of glucose and could potentially interfere with the efficacy of oral hypoglycemic drugs or insulin.


Diabetics and persons with blood glucose dysregulation should use InterFase® or InterFase®Plus under the supervision of a healthcare professional. As a precaution, persons taking anticoagulants, anti-DPP-IV medications, oral hypoglycemic agents, or insulin, and persons with gastritis, active peptic ulcers, gastroesophageal reflux disorder, or known damage to the gastrointestinal mucosa may wish to consult with a healthcare professional before using InterFase® or InterFase® Plus. InterFase® and InterFase® Plus may not be appropriate for persons with known allergies to Aspergillus organisms, though non-specific yeast or mold allergies do not necessarily preclude use of fungal-based enzymes. Lysozyme is derived from egg white protein and is highly purified, however, these products may not be appropriate for persons allergic to egg white. Pregnant or nursing women should consult with a healthcare professional before using InterFase® or InterFase® Plus

Serving Size 2 Capsules
Amount Per 2 Capsules % Daily Value
Sodium (as disodium EDTA) 30 mg 1%
Proprietary Enzyme/EDTA Blend 675 mg *
Providing the following active enzymes:
Polysaccharide Specific Enzymes
Glucoamylase (with isomaltase side chain activity) *
Chitosanase *
Cellulase *
Hemicellulase/Pectinase Complex *
Beta-Glucanase *
Protein and Peptide Specific Enzymes
Protease/Peptidase Complex with endopeptidase, exopeptidase, and DPP-IV activity *
Other Enzymes and EDTA
Lysozyme (from egg white) *
Serratia peptidase (enteric-coated)‡ *
EDTA (as disodium EDTA) *
* Daily value not established

Other Ingredients:

Vegetarian capsule (hydroxypropyl methylcellulose, water), ascorbyl palmitate, and microcrystalline cellulose.


‡Peptizyme SP®, a registered trademark of Specialty Enzymes.

Allergy Statement

 Free of the following common allergens: milk/casein, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.