SAMe (S-adenosylmethionine) is a metabolite present in all
living cells. It functions as a donor of methyl groups in over 100
different reactions and contributes to the synthesis, activation
and/or metabolism of hormones, neurotransmitters, nucleic
acids, phospholipids and proteins. Research indicates support for
positive mood, cell membrane fluidity, neurotransmitter synthesis,
glutathione production, joint comfort and healthy cell growth.*
Uses For SAMe
Cellular Function: SAMe functions as a donor of methyl groups
in over 100 different reactions catalyzed by methyltransferase
enzymes. Methyl groups act as a signal throughout the body,
regulating genetic expression and cellular function. Healthy
methylation is vital for cellular health, hormone and neurotransmitter
production, and energy metabolism. SAMe also functions as a
precursor molecule for glutathione and promotes polyamine
synthesis. Clinical trials indicate that SAMe administration enhances
glutathione production in hepatic tissue and red blood cells. The
polyamines spermidine and spermine maintain healthy cell growth
and cytokine balance.*
Cognitive Health: Over 40 clinical studies indicate that SAMe
promotes positive mood and cognitive function. In a metaanalysis
involving 25 controlled trials and 791 individuals, SAMe
offered statistically significant support for positive mood. While
the exact mechanism for this benefit has not been determined,
it is believed that SAMe supports neurotransmitter monoamine
synthesis and function, including dopamine and serotonin, through
SAMe-dependent methylation reactions. It also promotes healthy
protein turnover to support healthy CNS function and maintains
healthy phospholipid methylation to support phosphatidylcholine
production, as well as cellular membrane integrity and fluidity.*
Joint Function: Multiple clinical trials indicate that SAMe supports
joint comfort and flexibility. In a meta-analysis involving 11 studies,
SAMe offered statistically significant support for joint function. In
another 16-week, randomized, double-blind, placebo-controlled trial
involving 56 subjects, SAMe offered statistically significant support
for joint comfort. It is believed that SAMe enhances joint comfort and
function by supporting proteoglycan synthesis, and by helping to
stabilize and protect the proteoglycans.*
What Is The Source?
SAMe is derived from fermentation. Ascorbyl palmitate is derived
from corn dextrose fermentation and palm oil. Hypoallergenic plant
fiber is derived from pine cellulose. Gellan gum is derived from
Pure Encapsulations® recommends 1 capsule, 1–2 times daily, between meals.
Are There Any Potential Side Effects Or Precautions?
Consult your healthcare provider before use if you are pregnant
or nursing, taking antidepressant medication or if you have bipolar
disorder. In rare cases, SAMe has been associated with flatulence,
nausea, vomiting, diarrhea, constipation, dry mouth, headache,
mild insomnia, anorexia, sweating, dizziness and nervousness.
Anxiety and tiredness have occurred in people with depression, and
hypomania in people with bipolar disorder. Consult your physician
for more information.
Are There Any Potential Drug Interactions?
SAMe is contraindicated with anti-depressant medication,
dextromethorphan, and meperidine (Demerol). Concurrent use
might cause additive serotonergic effects and serotonin syndromelike
effects. It is also contraindicated with Levodopa. Consult your
physician for more information.